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Home - Products - Chromatin/Epigenetic - Sirtuin - SRT 1460

SRT 1460

CAS No. 925432-73-1

SRT 1460 ( SRT1460 )

Catalog No. M16630 CAS No. 925432-73-1

SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    SRT 1460
  • Note
    Research use only, not for human use.
  • Brief Description
    SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM.
  • Description
    SRT1460 is a potent, selective SIRT1 activator with EC1.5 of 2.9 uM, displays good selectivity for activation of SIRT1 versus SIRT2 and SIRT3 (EC1.5>300 uM) and is more potent than Resveratrol; improves insulin sensitivity, lowers plasma glucose, and increases mitochondrial capacity in obese mice model.
  • Synonyms
    SRT1460
  • Pathway
    Chromatin/Epigenetic
  • Target
    Sirtuin
  • Recptor
    Sirtuin
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    925432-73-1
  • Formula Weight
    507.61
  • Molecular Formula
    C26H29N5O4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(NC1=CC=CC=C1C2=CN3C(SC=C3CN4CCNCC4)=N2)C5=CC(OC)=C(OC)C(OC)=C5
  • Chemical Name
    3,4,5-Trimethoxy-N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Milne JC, et al. Nature. 2007 Nov 29;450(7170):712-6.
2. Pacholec M, et al. J Biol Chem. 2010 Mar 12;285(11):8340-51.
3. Hubbard BP, et al. Science. 2013 Mar 8;339(6124):1216-9.
4. Chini CC, et al. Clin Cancer Res. 2016 May 15;22(10):2496-507.
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